ncRNA name | hsa-miR-125b |
ncRNA Category | miRNA |
Disease name | cataract |
Species | Homo sapiens |
Tissues/Cell_line | anterior lens capsule; human lens epithelial cell line: SRA01/04 |
Methods | qRT-PCR, TUNEL assay, flow cytometry, Western blot, luciferase reporter assay |
Expression pattern | down-regulated |
Functional description | miR-125b was downregulated in both age-related cataract tissue and lens epithelial cell apoptosis induced by UV irradiation. In vitro, miR-125b regulates human lens epithelial cell apoptosis at least in part by directly targeting p53. |
PubMed ID | 25312242 |
Year | 2014 |
Title | MicroRNA-125b inhibits lens epithelial cell apoptosis by targeting p53 in age-related cataract. |
Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.